Unity 2021.3.25f1 on SDK 16.2.0 (the sdk build of Super Mario Bros. Wonder 1.0.0). The sdk build takes the node-area cut and SDK 20's 2 MB region alignment: Unity's N MB + 252 KB regions each took the next size class's slot, which exhausted the 4.375 GB alias region after about six minutes. Profile with a 1.5 GB pool, note, games table row, README gallery entry and reference entry.